Scientific approach to “Eat Well to Be Well”


Institute of Rheological Functions of Food

Representative Director

Takehiko Fujino

Laboratory Chief

Shiro Mawatari


2241-1 Kubara, Hisayama-machi, Kasuya-gun, Fukuoka 811-2501, Japan


March 28, 1995 by National Agriculture and Food Research Organization (Privatized in 2008)

Research Contents

Extraction of functional substances (physiologically active substance) from food
Evaluation of functional substances using the latest technology  

  • Evaluation of blood rheological properties (erythrocyte deformability)
  • Prevention of lifestyle-related diseases such as diabetes, hypertension and hyperlipidemia, clinical trial (animal, human)
  • Evaluation of immune function using visualization of intestinal immune function

Commercialization and commercialization support of immunologically functional food

For any enquiries, please contact us.
FAX:+81 92 976 2899

Research Papers

Fujino T, Yamada T, Asada T, Tsuboi Y, Wakana C, Mawatari S, Kono S. Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer's disease and mild cognitive impairment: a multicenter, randomized, double-blind, placebo-controlled trial. EBioMedicine. 2017 Mar 17:199-205. doi:

Mawatari S, Hazeyama S, Fujino T. Measurement of ether phospholipids in human plasma with HPLC-ELSD and LC/ESI-MS after hydrolysis of plasma with phospholipase A1. Lipids. 2016 Aug 51(8):997-1006.

Odashiro K, Saito K, Arita T, Maruyama T, Fujino T, Akashi K. Impaired deformability of circulating erythrocytes obtained from nondiabetic hypertensive patients: investigation by a nickel mesh filtration technique. Clin Hypertens. 2015 Oct 21:17.

Hoshuyama T, Odashiro K, Fukata M, Maruyama T, Saito K, Wakana C, Fukumitsu M, Fujino T. Mortality benefit of participation in BOOCS program: a follow-up study for 15 years in a Japanese working population. J Occup Environ Med. 2015 Mar 57(3):246-50.

Mawatari S, Katafuchi T, Miake K, Fujino T. Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats. Lipids Health Dis. 2012 Nov 11:161.

Ifuku M, Katafuchi T, Mawatari S, Noda M, Miake K, Sugiyama M, Fujino T. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. J Neuroinflammation. 2012 Aug 9:197.

Katafuchi T, Ifuku M, Mawatari S, Noda M, Miake K, Sugiyama M, Fujino T. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice. Ann N Y Acad Sci. 2012 Jul 1262:85-92.

Oma S, Mawatari S, Saito K, Wakana C, Tsuboi Y, Yamada T, Fujino T. Changes in phospholipid composition of erythrocyte membrane in Alzheimer's disease. Dement Geriatr Cogn Dis Extra. 2012 Jan 2(1):298-303.

Yunoki K, Renaguli M, Kinoshita M, Matsuyama H, Mawatari S, Fujino T, Kodama Y, Sugiyama M, Ohnishi M. Dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats. J Agric Food Chem. 2010 Jun 58(11):7030-5.

Ariyoshi K, Maruyama T, Odashiro K, Akashi K, Fujino T, Uyesaka N. Impaired erythrocyte filterability of spontaneously hypertensive rats: investigation by nickel filtration technique. Circ J. 2010 Jan 74(1):129-36.

Mawatari S, Yunoki K, Sugiyama M, Fujino T. Simultaneous preparation of purified plasmalogens and sphingomyelin in human erythrocytes with phospholipase A1 from Aspergillus orizae. Biosci Biotechnol Biochem. 2009 Dec 73(12):2621-5.

Mawatari S, Okuma Y, Fujino T. Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography. Anal Biochem. 2007 Nov 370(1):54-9.

Kuma F, Ueda N, Ito H, Maruyama T, Kaji Y, Fujino T, Harada M. Effects of ultrasound energy application on cardiac performance in open-chest Guinea pigs. Circ J. 2006 Oct 70(10):1356-61.

Iwata H, Ukeda H, Maruyama T, Fujino T, Sawamura M. Effect of carbonyl compounds on red blood cells deformability. Biochem Biophys Res Commun. 2004 Aug 321(3):700-6.

Okamoto K, Maruyama T, Kaji Y, Harada M, Mawatari S, Fujino T, Uyesaka N. Verapamil prevents impairment in filterability of human erythrocytes exposed to oxidative stress. Jpn J Physiol. 2004 Feb 54(1):39-46.

Mawatari S, Saito K, Murakami K, Fujino T. Absence of correlation between glycated hemoglobin and lipid composition of erythrocyte membrane in type 2 diabetic patients. Metabolism. 2004 Jan 53(1):123-7.

Mawatari S, Murakami K. Different types of glutathionylation of hemoglobin can exist in intact erythrocytes. Arch Biochem Biophys. 2004 Jan 421(1):108-14.

Murakami K, Mawatari S. Oxidation of hemoglobin to methemoglobin in intact erythrocyte by a hydroperoxide induces formation of glutathionyl hemoglobin and binding of alpha-hemoglobin to membrane. Arch Biochem Biophys. 2003 Sep 417(2):244-50.

Mawatari S, Ohnishi Y, Kaji Y, Maruyama T, Murakami K, Tsutsui K, Fujino T. High-cholesterol diets induce changes in lipid composition of rat erythrocyte membrane including decrease in cholesterol, increase in alpha-tocopherol and changes in fatty acids of phospholipids. Biosci Biotechnol Biochem. 2003 Jul 67(7):1457-64.


Patent No. 5062873

Patent No.5185539

Application No. 2013-249902

Application No. 2014-170286


Plasmalogens are a kind of phospholipids with antioxidant activity. They exist in all mammalian tissues and constitute about 18% of all phospholipids in human body. It has become evident that plasmalogens are enriched especially in brain neurons, cardiac muscle, lymphocyte and macrophage, and that they have control over primary functions of cells including antioxidation.

[PR] Click here to purchase from overseas.